In July 2020, the FDA approved Xywav (calcium, magnesium, potassium, and sodium oxybates) to treat cataplexy or EDS. In October 2020, Wakix was also approved by the FDA for the treatment of cataplexy in adults with narcolepsy. Sunosi was approved by the FDA to treat narcolepsy-related EDS. Wakix is the only drug currently approved to treat narcolepsy that is not a scheduled, controlled substance in the United States. Wakix (pitolisant) and Sunosi (solriamfetol) received approval in 2019. In the past 18 months, the FDA has approved three promising new medications for narcolepsy. Antidepressants like Effexor and Prozac (fluoxetine) have been prescribed for many decades to help treat cataplexy, the defining symptom of type 1 narcolepsy. Stimulants like Adderall (amphetamine/dextroamphetamine) and Ritalin (methylphenidate) are prescribed to combat EDS due to narcolepsy. Several medications are prescribed off-label to treat symptoms of narcolepsy. Xyrem is approved to treat cataplexy in type 1 narcolepsy.
Certain medications that block reuptake of serotonin or norepinephrine, like some antidepressants, may reduce cataplexy attacks. Drugs that have wake-promoting or stimulating effects are used to decrease EDS. Food and Drug Administration (FDA) to treat narcolepsy’s key symptoms - EDS, cataplexy, and other sleep disruptions. There are several medications approved by the U.S. Sodium oxybate also reduces sleep-cycle disruptions, including sleep paralysis and sleep-related hallucinations.Xyrem (sodium oxybate) and Effexor (venlafaxine) reduce the frequency and severity of cataplexy attacks.Stimulants and wakefulness-promoting drugs, such as Provigil (modafinil) and Nuvigil (armodafinil), enhance wakefulness.Goals of narcolepsy treatments work in different ways. Narcolepsy is usually treated with a combination of medication and lifestyle changes that promote good sleep hygiene.Ĭurrent narcolepsy treatments are aimed at managing the disruptive symptoms of narcolepsy that impact a person's quality of life. Narcolepsy treatment must be tailored for each person. Current Treatments for Type 1 and Type 2 Narcolepsy More treatments still under research in the development pipeline offer hope for those struggling to manage their narcolepsy symptoms. In the past two years, clinical research has led to several exciting new treatment options for narcolepsy.
The benefits of treatments have to be weighed with the risk of side effects, and they don’t always manage to bring symptoms under control. Current narcolepsy treatments are also predominantly controlled substances, due to their risk of abuse. Existing narcolepsy treatments often have significant side effects. In the past, people living with narcolepsy have had limited treatment options.
There currently is no cure for narcolepsy, but with medication and behavioral changes, the condition can be managed. Those who experience narcolepsy with EDS but without cataplexy are diagnosed with type 2 narcolepsy. Most people with narcolepsy have type 1 narcolepsy, also known as narcolepsy with cataplexy. Narcolepsy affects approximately 1 in 2,000 people. Narcolepsy is a chronic, neurological disorder characterised by excessive daytime sleepiness (EDS).
0 kommentar(er)
